OSU Biochemistry and Molecular Biology

Dr. Rita K. Miller




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 Research Tidbits

The cytoskeleton and positioning of the mitotic spindle

 In eukaryotic cells, the mitotic spindle is the cytoskeletal apparatus that segregates the genetic information contained in chromosomes to each of the daughter cells. The placement of mitotic spindle for a large number of cell types is actually found off-center. Asymmetric positioning of the mitotic spindle is an active process that permits the asymmetric distribution of cell-specificity determinants and the establishment of different cell fates. Incorrect spindle positioning can result in genetic instability due to chromosomal mis-segregation, which is an important component of many cancers. The work in my lab is focused on elucidating the molecular mechanisms that control spindle positioning. The Miller laboratory uses the model organism Saccharomyces cerevisiae (budding yeast), and is particularly interested in the post-translational mechanisms that regulate spindle positioning.

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