OSU Biochemistry and Molecular Biology

Dr. José Luis Soulages




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 Research Tidbits

Biochemistry and biophysics of lipids and lipoproteins

We study some aspects of transport, degradation, and synthesis of lipids.

Cholesterol: The concentration of cholesterol in human plasma is related to the probability of developing atherosclerorsis and cardiovascular disease. We are studying the mechanisms of cholesterol release from adipocytes to extracellular acceptors such as human high density lipoprotein (HDL) and apolipoprotein A-I (apoA-I).

Triacylglycerol: Triacylglycerol metabolism is highly related to the development of obesity and diabetes. A major goal of our studies is to understand the mechanisms of regulation of the rates of synthesis and degradation of triglyceride (TG) in adipose tissue. In collaboration with Dr. Estela Arrese we are studying the mechanisms of regulation of the rates of triacylglycerol synthesis and degradation in adipocytes (main cells present in adipose tissue) from mouse and insects. 


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