OSU Biochemistry and Molecular Biology

Dr. Donald Ruhl




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 Research Tidbits

In the Ruhl lab, we are interested in understanding how DNA, the molecular blueprint of an organism, is properly read and maintained. Errors in this process lead to disease, most notably cancers. Although a broad range of proteins are involved in this process, we are interested in the Swi/Snf chromatin remodeling complex due to the presence of several tumor suppressors. Using a variety of biochemical and cell-based approaches, we seek knowledge into the link between Swi/Snf function and cancer development. Insight into these processes will aid in the intelligent design of therapeutic drugs that target tumors arising from aberrations in Swi/Snf function.

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