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Patricia Ayoubi
| Research Area | Selected Publications | Lab Members |
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Title | Assistant Professor |
| Office | 360A NRC | |
| Phone | 405-774-6199 | |
| patricia.ayoubi@okstate.edu | ||
| Degree | Ph.D. Microbiology and Molecular Genetics. 1997. Oklahoma State University, Stillwater OK. | |
| Website |
Applied microarray analysis, bioinformatics, genomics, and DNA/genome sequence analysis
The Ayoubi lab uses advanced technologies and genomics approaches including DNA microarray analysis, bioinformatics, genomics, EST and genome sequence analysis to study a variety of biological problems. Recent studies include Anaplasma phagocytophilum modulation of gene expression in human host cells; specific induction and relief from carbon catabolite repression as two systems involved in expression of genes needed for metabolism of complex polysaccharides; and gene expression patterns during carbon deprivation and pectin metabolism by the filamentous fungus Aspergillus nidulans. Bioinformatics tools such as PipeOnLine and GenePix Auto-Processor have been developed to assist in automated processing of large-scale biological data. PipeOnline is a web-based integration of tools designed to process DNA sequence data and generate online pubic and private databases. GenePix Auto-Processor (GPAP) is a web-based interface for second level preprocessing and statistical analysis of primary expression data obtained from microarray image processing.
Selected Publications (top)
Galindo RC, Ayoubi P, García-Pérez AL, Naranjo V, Kocan KM, Gortazar C, de la Fuente J. 2008. Differential expression of inflammatory and immune response genes in sheep infected with Anaplasma phagocytophilum. Vet. Immunol. Immunopathol. 126:27-34.
de la Fuente J, Maritz-Olivier C, Naranjo V, Ayoubi P, Nijhof AM, Almazán C, Canales M, Pérez de la Lastra JM, Galindo RC, Blouin EF, Gortazar C, Jongejan F, Kocan KM. 2008. Evidence of the role of tick subolesin in gene expression. BMC Genomics. 9:372.
Fernández de Mera IG, Pérez de la Lastra JM, Ayoubi P, Naranjo V, Kocan KM, Gortazar C, de la Fuente J. 2008. Differential expression of inflammatory and immune response genes in mesenteric lymph nodes of Iberian red deer. Dev. Comp. Immunol. 32:85-91.
Ross JW, Ashworth MD, White FJ, Johnson GA, Ayoubi PJ, DeSilva U, Whitworth KM, Prather RS, Geisert RD. 2007. Premature estrogen exposure alters endometrial gene expression to disrupt pregnancy in the pig. Endocrinology. 48:4761-4773.
Bernardo A, Bai G, Guo P, Xiao K, Guenzi AC, Ayoubi P. 2007. Fusarium graminearum-induced changes in gene expression between Fusarium head blight-resistant and susceptible wheat cultivars. Funct Integr Genomics. 7:69-77.
Mahalingam R, Jambunathan N, Gunjan SK, Faustin E, Weng H, Ayoubi P. 2006. Analysis of oxidative signaling induced by ozone in Arabidopsis thaliana. Plant Cell Environ. 29:1357-71.
Naranjo V, Ayoubi P, Vicente J, Ruiz-Fons F, Gortazar C, Kocan KM, de la Fuente J. 2006. Characterization of selected genes upregulated in non-tuberculous European wild boar as possible correlates of resistance to Mycobacterium bovis infection. Vet Microbiol. 116:224-31
de la Fuente J, Ayoubi P, Blouin EF, Almazán C, Naranjo V, Kocan KM. 2006. Anaplasmosis: focusing on host-vector-pathogen interactions for vaccine development. Ann N Y Acad Sci. 1078:416-423.
Park SJ, Huang Y, Ayoubi P. 2006. Identification of expression profiles of sorghum genes in response to greenbug phloem-feeding using cDNA subtraction and microarray analysis. Planta. 223:932-947.
Pócsi I, Miskei M, Karányi Z, Emri T, Ayoubi P, Pusztahelyi T, Balla G, Prade RA. 2005. Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology. BMC Genomics. 6:182.
Donnelly BE, Madden RD, Ayoubi P, Porter DR, and Dillwith JW. 2005 The wheat (Triticum aestivum L.) leaf proteome. Proteomics.5:1624-1633
