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Linda Yu
| Research Area | Selected Publications | Lab Members |
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Title | Professor |
| Office | 253A NRC | |
| Phone | 405-744-6196 | |
| linda.yu@okstate.edu | ||
| Degree | Ph.D. Microbiology. 1970. University of Illinois, Urbana, IL. | |
| Website |
Bioenergetics in mitochondrial and photosynthetic bacterial electron transfer systems
Dr. Linda Yu’s research interests are in the area of bioenergetics with special emphasis on the structural and functional studies of the supernumerary subunit (non-redox containing subunit) in the cytochrome bc1 complex. She uses the bc1 complex from Rhodobacter sphaeroides as a model system for this study, because this complex contains only one supernumerary subunit, subunit IV. Dr. Yu uses site-directed mutagenesis coupled with in vitro reconstitution, physical measurements, and X-ray crystallography techniques for the study. She plans to obtain the structure of this bacterial complex in high resolution and to study the mode of interactions between the three-subunit core complex and subunit IV. She will also study the role of subunit IV involved in superoxide radical production by the bc1 complex.
Yu, L., Yang, S-Q., Yin, Y., Cen, X., Zhou, F. Xia, D. Yu, C.A.(2009) Analysis of electron transfer and superoxide generation in the cytochrome bc1 complex. Meth. In Enzymol. 456, 459-473.
Yin, Y., Tso,S-C., Yu, C. A., and Yu, L. (2009) Effect of subunit IV on superoxide generation by Rhodobacter sphaeroides cytochrome bc1 complex. Biochim. Biophy. Acta. 1787, 913-919.
Wang, Q-Y., Yu, L. and Yu, C. A. (2009) Crosstalk between Mitochondrial Malate Dehydrogenase and Cytochrome bc1 Complex. J. Biol. Chem. 284, in press.
Shaoqing Yang, Ying Yin, Di Xia, Linda Yu, Chang-An Yu (2009) Reaction mechanism of superoxide generation during ubiquinol oxidation by the cytochrome bc1 complex. J. Biol. Chem. Submitted.
Ma, H-W., Yang, S., Yu, L., and Yu, C. A. 2008. Formation of Engineered Inter-Subunit Disulfide Bond in Cytochrome bc1 Complex Disrupts Electron Transfer Activity in the Complex. Biocim. Biophys Acta. 1777, 317-326.
Cen, X., Yu, L., and Yu, C. A. 2008. Domain Movement of Iron Sulfur Protein in Cytochrome bc1 Complex Is Facilitated by the Electron Transfer from Cytochrome bL to bH. FEBS Lett. 582, 523-526
Yu, C. A., Cen, X., Ma, H-W., Yu, L., Esser, L., and Xia, D. 2008. Domain Conformational Switch of the Iron Sulfur Protein in Cytochrome bc1 Complex Is Induced by the Electron Transfer from Cytochrome bL to bH. Biochim. Biophy. Acta. 177, 1038-1043.
Yang, S., Ma, H-W., Yu, L., and Yu, C-A. 2008. On the mechanism of ubiquinol oxidation at Qp Site in cytochrome bc1 complex: Studied by mutants without cytochrome bL or bH. J. Biol. Chem. 283, 28767-28776.
Gurung, B., Yu, L., and Yu, C. A. 2008. Stigmatellin induces the reduction of the Rieske [2Fe-2S] cluster of cytochrome bc1 complex in the absence of an apparent electron source. J. Biol. Chem. 283, 28087-28094.
Xia, D., Esser, E., Elberry, M., Zhou,F., Yu, L., and Yu, C-A. 2008. The road to the crystal structure of the cytochrome bc1 complex from the anoxigenic, photosynthetic bacterium Rhodobacter sphaeroides. J. Bioenergetic Biomembrane. 40, 485-492.
Gurung, B., Yu, L., and Yu, C. A. (2008) Stigmatellin induces the reduction of the Rieske [2Fe-2S] cluster of cytochrome bc1 complex in the absence of an apparent electron source. Biochemistry. In press.
Yu, C. A., Cen, X., Ma, H-W., Yu, L., Esser, L., and Xia, D. (2008) Domain Conformational Switch of the Iron Sulfur Protein in Cytochrome bc1 Complex Is Induced by the Electron Transfer from Cytochrome bL to bH. Biochim. Biophy. Acta. In press.
Cen, X., Yu, L., and Yu, C. A. (2008) Domain Movement of Iron Sulfur Protein in Cytochrome bc1 Complex Is Facilitated by the Electron Transfer from Cytochrome bL to bH. FEBS Lett. In press.
Ma, H-W., Yang, S., Yu, L., and Yu, C. A. (2008) Formation of Inter-Subunit Disulfide Bond in Cytochrome bc1 Complex Disrupts Electron Transfer Activity in the Complex. Biocim. Biophys Acta. In press.
Esser, L., Elberry, M., Zhou, F., Yu, L., Yu, C. A., and Xia, D. (2008) Inhibitor Complexed Structure of the Cytochrome bc1 from the Photosynthetic Bacterium Rhodobacter sphaeroides. J. Biol. Chem. 283, 2846-2857.
Xia, D., Esser, L., Yu, L., and Yu, C. A. (2007) Structural Basis for the Mechanism of Electron Bifurcation at the Quinol Oxidation Site of the Cytochrome bc1 Complex. Photsynthesis Research, 92, 17-34.
Rajagukguk, S., Yang, S., Yu, C. A., Yu, L., Durham, B., and Millett, F. (2007) Effect of Mutations in the Cytochrome b ef Loop on the Electron-Transfer Reactions of the Rieske Iron-Sulfur Protein in the Cytochrome bc1 Complex. Biochemistry 46, 1791-1798.
Jian Zhu, Tsuyoshi Egawa , Syun-Ru Yeh, Linda Yu and Chang-An Yu. Fast Kinetic Studies of Mitochondrial Cytochrome bc1 Complex. Proc. Natl. Acad. Sci. USA, 104, 4864-4869.
X., Liu, X., Gong, D. B., Hicks, T. A., Krulwich, L., Yu, and C. A., Yu, (2007) Interaction between Cytochrome caa3 and F1F0-ATP Synthase of AlkaliphilicBacillus pseudofirmus OF4 Is Demonstrated by Saturation Transfer Electron Paramagnetic Resonance and Differential Scanning Calorimeter Assays. Biochemistry. 46, 306-313.
