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Benjamin Sandler

     Research Area          Selected Publications           Lab Members     
 Title Assistant Professor
 Office 246C NRC
 Phone 405-744-6194
 Email benjamin.sandler@gmail.com
 Degree Ph.D. Chemistry & Chemical Biology. 2000. Cornell University, Ithaca, NY
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Research Area (top)

Teaching the language of science

The usefulness of mathematics lies in the fact that it is a very precise language.  But, math education typically focuses solely on the ability to "crunch the numbers" and get a correct answer.  As a result, students in the sciences are all too often able to manipulate numbers and equations with great skill, without understanding the reality that the equations represent.  I am developing a teaching methodology that will teach mathematics as a language.  My goal is for a student to look at an equation and understand its meaning as easily as he or she can look at the phrase "the green apple" and see a fruit in the mind's eye. As an X-ray crystallographer, I am also collaborating with Dr. Massiah on structural studies of midline-1. 

Selected Publications (top)

Togashi, M., Borngraeber, S., Sandler, B., Fletterick, R.J., Webb, P., & Baxter, J.D. (2005) Conformational adaptation of nuclear receptor ligand binding domains to agonists: Potential for novel approaches to ligand design. J. Steroid Biochem. Mol. Biol. 93, 127-137.

Sandler, B., Webb, P., Apriletti, J. W., Huber, B. R., Togashi, M., Cunha Lima, S. T., Juric, S., Nilsson, S., Wagner, R., Fletterick, R. J., & Baxter, J. D. (2004) Thyroxine-thyroid hormone receptor interactions. J. Biol. Chem. 279, 55801-55808.

Huber, B. R., Sandler, B., West, B. L., Cunha Lima, S. T., Nguyen, H. T., Apriletti, J. W., Baxter, J.D., & Fletterick, R. J. (2003) Two resistance to thyroid hormone mutants with impaired hormone binding. Mol. Endocrinol. 17, 643-652.

Sandler, B. H., Baxter, J. D., & Fletterick, R. J. (2003) Learning from Nature’s Experiments on the Thyroid Hormone Receptor; X-Ray Structures of RTH Mutant Ligand-Binding Domains.  In Beck-Peccoz, P., ed., Syndromes of hormone resistance in the hypothalamic-pituitary-thyroid axis. 

Sandler, B. H., Nikonova, L., Leal, W. S., & Clardy, J. (2000) Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Chem. Biol. 7, 143-151. 

Sandler, B., Murakami, M., & Clardy, J. (1998) Atomic Structure of the Trypsin-Aeruginosin 98-B Complex. J. Am.Chem.Soc. 120, 595-596.

Lab Members (top)